Dolbier HW Solutions 459

Dolbier HW Solutions 459 - 553 CARBOXYLIC ACID DERIVATIVES:...

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( i ) The amide nitrogen bears two methyl groups. We designate this as an N , N -dimethyl amide. 20.27 ( a ) Acetyl chloride acts as an acyl transfer agent to the aromatic ring of bromobenzene. The reac- tion is a Friedel Crafts acylation. Bromine is an ortho, para-directing substituent. ( b ) Acyl chlorides react with thiols to give thioesters. ( c ) Sodium propanoate acts as a nucleophile toward propanoyl chloride. The product is propanoic anhydride. ( d ) Acyl chlorides convert alcohols to esters. ( e ) Acyl chlorides react with ammonia to yield amides. 1 Cl CCl O p -Chlorobenzoyl chloride Cl CNH 2 O p -Chlorobenzamide NH 3 Ammonia 1 CH 3 CH 2 CH 2 CCl O Butanoyl chloride
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.

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