Dolbier HW Solutions 461

Dolbier HW Solutions 461 - 555 CARBOXYLIC ACID DERIVATIVES...

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( l ) The starting material is a cyclic ester, a lactone. Esters undergo saponi f cation in aqueous base to give an alcohol and a carboxylate salt. ( m ) Ammonia reacts with esters to give an amide and an alcohol. ( n ) Lithium aluminum hydride reduces esters to two alcohols; the one derived from the acyl group is a primary alcohol. Reduction of a cyclic ester gives a diol. ( o ) Grignard reagents react with esters to give tertiary alcohols. ( p ) In this reaction methylamine acts as a nucleophile toward the carbonyl group of the ester. The product is an amide. ( q ) The starting material is a lactam, a cyclic amide. Amides are hydrolyzed in base to amines and carboxylate salts. 1 Sodium hydroxide NaOH Sodium 4-(methylamino)butanoate
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.

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