(r)In acid solution amides yield carboxylic acids and ammonium salts.(s)The starting material is a cyclic imide. Both its amide bonds are cleaved by nucleophilic attackby hydroxide ion.(t)In acid the imide undergoes cleavage to give a dicarboxylic acid and the conjugate acid ofmethylamine.(u)Acetanilide is hydrolyzed in acid to acetic acid and the conjugate acid of aniline.(v)This is another example of amide hydrolysis.(w)One way to prepare nitriles is by dehydration of amides.1H2OCyclopentanecarboxamideOCNH2Cyclopentyl cyanideCNP4O10111WaterH2OSulfuric acidH2SO4N-MethylbenzamideOC6H5CNHCH3BenzoicacidOC6H5COHMethylammoniumhydrogen sulfateCH3NH3HSO4211WaterH2
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.