(x)Nitriles are hydrolyzed to carboxylic acids in acidic media.(y)Nitriles are hydrolyzed in aqueous base to salts of carboxylic acids.(z)Grignard reagents react with nitriles to yield ketones after addition of aqueous acid.(aa)Amides undergo the Hofmann rearrangement on reaction with bromine and base. A methylcarbamate is the product isolated when the reaction is carried out in methanol.(bb) Saponifcation of the carbamate in part (aa) gives the corresponding amine.20.28(a)Acetyl chloride is prepared by reaction of acetic acid with thionyl chloride. The frst task thenis to prepare acetic acid by oxidation of ethanol.(b)Acetic acid and acetyl chloride, available from part (a), can be combined to form aceticanhydride.
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.