F08-BCH361-L3

F08-BCH361-L3 - Amino acids and peptides 1 From amino acids...

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Amino acids and peptides 1
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From amino acids to protein structure Sequence of amino acids Secondary structure elements Folded protein Final functional oligomeric complex The sequence of the amino acids determines the structure and function of the protein(complex) 3
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Amino acids: constituents of proteins 4
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Amino-acids are chiral molecules all proteins and most peptides consist only of L-amino acids 5
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Zwitterionic form of amino acids Zwitterions: compounds that each have both positive and negative charges Netcharge +1 Netcharge 0 isoelectric point Netcharge -1 Zwitter (german) (Hermaphrodite, hybrid) 8
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The amino acid side chains determine the structure and function of the protein They can be divided into A) non-polar side chains B) polar uncharged side chains (at pH 7 ) C) basic side chains D) acidic side chains 9
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Non-polar amino acids with aliphatic side chains Alanine Ala A Leucine Leu L Isoleucine Ile I Valine Val V 10
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Non-polar amino acids with aromatic side chains Tryptophane Trp W Phenylalanine Phe F 11
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Other non-polar amino acids Methionine Met M Proline Pro P Glycine Gly G 12
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polar non-charged amino acids with OH group Serine Ser S Threonine Thr T Tyrosine Tyr Y 13
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polar non-charged amino acids with amide group Glutamine Gln Q Asparagine Asn N 14
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polar non-charged amino acid with SH group 15 cysteine
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The native structure of many proteins is stabilized by disulfide bridges 16
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basic amino acids Lysine Lys K Arginine Arg R Histidine His H (! His is 50% protonated at pH 7) 17
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This note was uploaded on 09/30/2011 for the course BCH 361 taught by Professor Fromme during the Fall '08 term at ASU.

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F08-BCH361-L3 - Amino acids and peptides 1 From amino acids...

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