F08-BCH361-L8

F08-BCH361-L8 - Nucleic Acids Structure of DNA and RNA The...

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Nucleic Acids Structure of DNA and RNA
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The monomers of nucleic acids are nucleosides RNA DNA Ribose Deoxyribose
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a nucleoside consists of an organic base Cytosine, Thymine, Adenosine or Guanine C T(U*) A G (* in RNA) covalently glycosidic linked to either ß-D-Ribose => Ribonucleoside or ß-D-Deoxyribose => Deoxyribonucleotide
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Structures of nucleobases CU T G A
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Structures of commonly occurring nucleotides I AMP dAMP dGMP GMP
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Structures of commonly occurring nucleotides II UMP CMP dCMP dTMP
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Both DNA and RNA consist of nucleotides joined by phosphodiesterbonds to form a sugar phosphate backbone
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A Fragment of the RNA chain
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A fragment of the DNA chain
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Secondary structure of DNA: The double helix
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3’ end 3’ end 5’ end 5’ end 34 Å = one complete turn Large groove 22 Å Small groove 12 Å the two strands have antiparallel polarity
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Base pairing A = T two H-bonds G C three H-bonds
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base stacking: the hydrophobic ring systems of the bases form hydrophobic interactions, leading to a stacking of the bases
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Conformational Variations in DNA The B- A- and Z- form of the DNA The B-DNA occurs most commonly in nature
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F08-BCH361-L8 - Nucleic Acids Structure of DNA and RNA The...

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