F08-BCH361-L20

F08-BCH361-L20 - Major pathways of carbohydrate metabolism....

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• Major pathways of carbohydrate metabolism. Fig 8.1 3 rd ed
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The Glycolytic Pathway Figure 14.1 Glucose is converted to 2 pyruvate
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Pyruvate to Acetyl-CoA • Under aerobic conditions, pyruvate undergoes oxidative decarboxylation – the carboxylate group is converted to CO 2 – the remaining two carbons are converted to the acetyl group of acetyl-CoA Pyruvate CH 3 CSCoA + CO 2 + NADH O Acetyl-CoA oxidative decarboxylation CH 3 C COO - + NAD + + CoASH O
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pyruvate to acetyl CoA 2 NADH Citric acid cycle 2 molecules of GTP (or ATP) in citric acid cycle + 6 NADH + 2 FADH 2 Oxidative phosphorylation 8 NADH gives 24 ATP 2 FADH 2 gives 4 ATP 28 ATP +2 = 30 ATP
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Lactate fermentation Glucose + 2 ADP + 2Pi Lactate + 2 ATP 2 ATP 60.3 kJ /mole Alcohol fermentation Glucose + 2 ADP + 2Pi Ethanol + CO 2 + 2ATP 2 ATP 60.6 kJ / mole Respiration (maximal amount , including 2 ATP and 2 NADH (= 6 ATP) from glycolysis ) Glucose + 38 ADP + 38Pi +6O 2 6CO 2 + 38H 2 O + 38ATP 38 ATP 1151 kJ / mole
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Gluconeogenesis Substrates • In the Cori cycle , lactate from skeletal muscle is transferred to the liver where it is converted to pyruvate then glucose. • Glycerol (fats) enters gluconeogenesis in the liver via glycerol-3-P then DHAP. • In the alanine cycle , pyruvate in muscles is converted to alanine, which is transported to the liver and reconverted to pyruvate. This cycle also transports NH 4 + to the liver!!
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This note was uploaded on 09/30/2011 for the course BCH 361 taught by Professor Fromme during the Fall '08 term at ASU.

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F08-BCH361-L20 - Major pathways of carbohydrate metabolism....

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