F08-BCH361-L24

F08-BCH361-L24 - Lipid metabolism Nucleus: nucleic acid...

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
Lipid metabolism
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cytosol: fatty acid synthesis, and activation , glycolysis, most gluconeogenesis reactions, pentose phosphate pathway Nucleus: nucleic acid synthesis Endoplasmic reticulum: synthesis of lipids for membranes , delivery of proteins Mitochondria: citric acid cycle, respiration, fatty acid breakdown
Background image of page 2
Degradation of fatty acids takes place in the matrix of mitochondria
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fatty Acids and Energy • Fatty acids in triacylglycerols are the principal form of energy storage for most organisms – their carbon chains are in a highly reduced form – the energy yield per gram of fatty acid oxidized is greater than that per gram of carbohydrate oxidized
Background image of page 4
equation from these are stored:
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Sources of fatty acids can be triacylglyeroles or phospholipids A triacylglycerol CH 2 O- CR O O 2 RCO - RC -OCH H 2 O Glycerol Lipases O Phospholipases A glycerylphosphoryl- choline H 2 O Re-use Oxidation A phosphatidyl choline O 2 O 2 O-POCH 2 2 N(CH 3 ) 3 O O - O +
Background image of page 6
The ester bonds between glycerol and the fatty acids are hydrolyzed by phospholipases • different phospholipases have different sites of action CH 2 O- C- R 2 O O 2 O- P- O- R ' R 1 -C-O-CH O - O A 1 A 2 CD
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Phospholipase D is present in the venom of spiders snake venom also contains phospholipases, which hydrolyze red blood cells
Background image of page 8
The degradation of fatty acids is regulated by hormones
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 10
the first step of the fatty acid degradation is the “activation” by binding of the fatty acid to acyl- CoA for this step even ATP is hydrolyzed to AMP, the latter has to be recycled to ADP by use of another molecule of ATP, so a total of 2 ATP are consumed in this step
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/30/2011 for the course BCH 361 taught by Professor Fromme during the Fall '08 term at ASU.

Page1 / 34

F08-BCH361-L24 - Lipid metabolism Nucleus: nucleic acid...

This preview shows document pages 1 - 12. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online