F08-BCH361-L26

F08-BCH361-L26 - Respiration: Electron Transport and...

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Respiration: Electron Transport and Oxidative Phosphorylation
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Respiration • Carried out by four multisubunit membrane- bound complexes •a n d two electron carriers, coenzyme Q (ubiquinone) and cytochrome c – in a series of oxidation-reduction reactions, electrons from FADH 2 and NADH are transferred from one complex to the next until they reach O 2 –O 2 is reduced to H 2 O - as a result of electron transport, protons are pumped across the inner membrane to the intermembrane space 2H 2 O + 4H + + 4e - O 2
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Coupling of Oxidation and Phosphorylation – the energy-releasing oxidations give rise to proton pumping and a pH gradient across the inner mitochondrial membrane – in addition, differences in the concentration of ions across the membrane generate a voltage gradient – a coupling process converts the electrochemical potential to the chemical energy of ATP – the coupling factor is ATP synthase, a membrane protein complex. Separate from the electron transport complexes, it is similar to the enzyme from chloroplasts.
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The F 0 -F 1 complex (ATP -Synthase) can be seen in electron micrographs
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production of vesicles from the inner mitochondrial membranes
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Mechanism of Ox/Phos • Evidence for chemiosmotic coupling – a system with definite inside and outside compartments (closed vesicles) is essential – submitochondrial vesicles can be prepared, which carry out oxidative phosphorylation and have an asymmetric orientation of respiratory complexes – a model system for oxidative phosphorylation can be
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F08-BCH361-L26 - Respiration: Electron Transport and...

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