{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

F08-BCH361-L27

F08-BCH361-L27 - Lecture 27 Live or let die The protection...

Info iconThis preview shows pages 1–16. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 27 Live or let die: The protection from cancer and aging The cell response to the tumor supressor protein p53
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The life of most cells that acquire potentially malignant characteristics is rapidly terminated, leaving only rare incipient cancer cells in which defects in the apoptotic response allow survival and further malignant progression .
Background image of page 2
Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and survive only because they have acquired lesions — such as loss of p53 — that prevent or impede cell death. The aim of the present research is to understand the complex mechanisms that regulate whether or not a cell dies in response to p53 — insights that will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon