Wilson's Disease.docx - \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 \u2022 DELIRIUM CONFUSION DEMENTIA FORGETFULLNESS EASILY CINFUSED ATAXIA(DIFFICULTY WALKING

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DELIRIUM ( CONFUSION ) DEMENTIA ( FORGETFULLNESS : EASILY CINFUSED) ATAXIA (DIFFICULTY WALKING ) ABDOMINAL DISTENSION ( ENLARGEMENT OF ABDOMEN ) NEUROSES(PHOBIAS)(BRAIN ) VOMITING BLOOD (KIDNEYS FAILING ) ICTERUS ( JAUNDICE OF EYES OR SKIN ) ( LIVER FAILING ) TREMORS OF HANDS OR ARMS ( BRAIN / NERVOUS SYSTEM ) SPEECH IMPAIRMENT (BRAIN ) • WEAKNESS EMOTIONAL AND BEHOVIATAL CHANGES ( BRAIN )
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Symptoms Neuropsychiatric Symptoms Clumsiness Behavioral changes Hand tremor Slurred speech Seizures Front lobe disorders - Impaired judgment, promiscuity, Dementia Depression Anxiety Hepatic Symptoms Tiredness Portal hypertension Chronic active hepatitis Jaundice
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Neurologic manifestations: 98% have Kayser-Fleischer rings Classification: dysarthric, dystonic, tremulous, pseudosclerotic or parkinsonian Chorea, dementia, seizures, hyperreflexia, autonomic dysfunction, risus sardonicus Psychiatric symptoms: Earlier presentation Depression is the most common sign Hepatic manifestations: Range from asymptomatic disease to acute liver failure Younger patients develop acute hepatitis with ↑AST, jaundice, abdominal pain Acute liver failure – Coomb’s negative hemolytic anemia , low uric acid, normal/low-normal alkaline phosphatase , coagulopathy, renal failure
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Hepatic manifestations: presentation Hepatic Manifestations Asymptomatic hepatomegaly Persistently abnormal AST and ALT Fatty liver Cirrhosis
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  • Fall '16
  • acute liver failure, Hepatology, Wilson's disease

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