2011 Hypothalamus and Pituitary

2011 Hypothalamus and Pituitary - Dr Kennon M Garrett...

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E-16 Dr. Kennon M. Garrett HYPOTHALAMUS AND PITUITARY Reading: Vander et al., Human Physiology, 12 th ed. pp. 325-331. Behavioral Objectives 1. List the components of the hypothalamic-pituitary axis. 2. List the hormones secreted by the hypothalamus, anterior pituitary and posterior pituitary. 3. List the steps of hormone release from the hypothalamus, anterior pituitary and endocrine glands. 4. Describe the negative feedback regulation of the release of anterior pituitary hormones. 5. List the 4 mechanisms of endocrine disorders. I. Anatomy of Hypothalamus and Pituitary A. Pituitary 1. Location - sella turcica in sphenoid bone 2. Posterior pituitary outgrowth of hypothalamus - neuronal tissue
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E-17 3. Anterior pituitary tissue originating from Rathke’s pouch in the pharynx 4. Infundibulum (hypophyseal stalk) B. Hypothalamus 1. Median eminence - base of hypothalamus 2. Hypothalamic-pituitary portal vessels II. Posterior Pituitary A. Oxytocin octapeptide - cys-tyr- ile -gln-asn-cys-pro- leu -gly stimulates milk ejection reflex and stimulates uterine contractions B. Vasopressin (antidiuretic hormone, ADH) – octapeptide - cys-tyr- phe -gln-asn-cys-pro- arg -gly regulates water reabsorption in collecting ducts III. Hypothalamus A. Hypophysiotropic hormones (Fig. 11-17) 1. Hypophysiotropic (trophic) hormones are released from the hypothalamus and regulate release of hormones from anterior pituitary.
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