What are Biomarkers?Measurable indicators of any biological stateMany markers are related to healthFor example:B.P,antibody,Temperature are measurable indicators to detect physiological state of bodyBlood pressure is a type of biomarker related to health to detect heart stroke.Antibody to detect infection or diseaseHigh temperature to detect fever
Why biomarkers are important?We can not find any physiological state without knowing particular feature or parameter(biomarker).Change in these parameters is detectable.By detecting that parameter we can check that whether body’s physiological state is normal or not.Whether body condition is normal or diseased
DNA biomarkers•A measurable DNA characteristic that is an indicator of normal biological processes,pathogenic processes or response to the therapeutic or other interventions•Scientists have discovered that virtually all cancers carry somatic DNA mutations.Unlike hereditary mutations that are passed from parent to child and are present in every cell in body,somatic mutations form in the DNA of individual cells during a person’s life.Because these somatic mutations are only present in tumor cell DNA ,they provide an extremely specific biomarker that can be detected and tracked•Mutations in oncogenes,tumor suppressor gene and mismatch repair gene can serve as DNA biomarkers
Types of DNA Markers1.Restriction fragments length polymorphism(RFLP)2.Random amplified polymorphic DNA(RAPD)
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