Case Study 3-LAD

Case Study 3-LAD - Case 3: Leukocyte Adhesion Deficiency...

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Case 3: Leukocyte Adhesion Deficiency
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Related Topics Migration and homing of leukocytes Phagocytic cell defects Adhesion molecules in T-cell interactions Bone marrow transplantation Complement receptors
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Blood Cells Red blood cells, monocytes, granulocytes, and B lymphocytes are produced in the bone marrow T lymphocytes are produced in the thymus Red blood cells will spend most of their lives in the bloodstream, while white blood cells move in and out of the bloodstream in order to perform their effector function.
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Leukocytes Lymphocytes circulate through secondary lymphoid structures Monocytes mature in tissue to become macrophages Granulocytes and effector T lymphocytes are called to extravascular region, meaning they must transverse the vascular endothelium (Nearly 3 billion neutrophils enter the oral cavity each day)
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Migration of Neutrophils Neutrophils move through the vascular system by clinging to the inner wall of the blood vessels Molecules known as adhesion molecules slow down and stop the leukocytes over the place in need of aid The neutrophils then shift into a shape that makes it possible for them to squeeze between and make it through the vascular endothelium LFA-1 and Mac-1 are leukocyte integrins that help bind the leukocyte to the stick receptors
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Case Study 3-LAD - Case 3: Leukocyte Adhesion Deficiency...

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