Case Study 3-LAD - Case 3 Leukocyte Adhesion Deficiency...

Info icon This preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Case 3: Leukocyte Adhesion Deficiency
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Related Topics Migration and homing of leukocytes Phagocytic cell defects Adhesion molecules in T-cell interactions Bone marrow transplantation Complement receptors
Image of page 2
Blood Cells Red blood cells, monocytes, granulocytes, and B lymphocytes are produced in the bone marrow T lymphocytes are produced in the thymus Red blood cells will spend most of their lives in the bloodstream, while white blood cells move in and out of the bloodstream in order to perform their effector function.
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Leukocytes Lymphocytes circulate through secondary lymphoid structures Monocytes mature in tissue to become macrophages Granulocytes and effector T lymphocytes are called to extravascular region, meaning they must transverse the vascular endothelium (Nearly 3 billion neutrophils enter the oral cavity each day)
Image of page 4
Migration of Neutrophils Neutrophils move through the vascular system by clinging to the inner wall of the blood vessels Molecules known as adhesion molecules slow down and stop the leukocytes over the place in need of aid The neutrophils then shift into a shape that makes it possible for them to squeeze between and make it through the vascular endothelium LFA-1 and Mac-1 are leukocyte integrins that help bind the leukocyte to the stick receptors
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
http://www.youtube.com/watch?v=I9zSe0qmXGw&feature=
Image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern