(h)Acetanilide is a reactive substrate toward electrophilic aromatic substitution. On reaction withchloroacetyl chloride, it undergoes Friedel–Crafts acylation, primarily at its para position.Acylation, rather than alkylation, occurs. Acyl chlorides are more reactive than alkyl chloridestoward electrophilic aromatic substitution reactions as a result of the more stable intermediate(acylium ion) formed.(i)Reduction with iron in hydrochloric acid is one of the most common methods for convertingnitroarenes to arylamines.(j)Primary arylamines are converted to aryl diazonium salts on treatment with sodium nitrite inaqueous acid. When the aqueous acidic solution containing the diazonium salt is heated, aphenol is formed.(k)This problem illustrates the conversion of an arylamine to an aryl chloride by the Sandmeyerreaction.(l)Diazotization of primary arylamines followed by treatment with copper(I) bromide converts
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This note was uploaded on 10/03/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.