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Test4Notes - Test 4 BLOOD Blood Functions:- Distributive o...

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Unformatted text preview: Test 4 BLOOD Blood Functions:- Distributive o Delivers oxygen and nutrients to all cells o Carries metabolic wastes to elimination sites o Carries hormones to target organs o Maintains body temperature; absorbs and distributes heat 22-25% of cardiac output is put toward cooling purposes during hot humid weather, rather than carrying nutrients and oxygen to the muscles and organs - Protective o Maintains normal pH of tissues o Maintains circulatory volume If you go give blood, your circulatory volume will be back to normal very quickly o Prevents blood loss o Combats infection Physical Characteristics of Blood (FYI*)- Viscosity= 4.5-5.5- Temperature= 38 degrees C/ 100.4 degrees F- pH= 7.35-7.45- NaCl (normal saline)concentrations= .85%- .90%- Total body weight= 8%- Volume= 4-5 L for women, 5-6 L for men Slide 3- Good overview of components of blood (Figure 13.01) Hematopoiesis (Hemopoiesis)- blood cell formations- Occurs in: (All blood cells, start in the myeloid tissue [red marrow/spongy bone]) o Myeloid tissue (begin and fully completed) Erythrocytes (rbc-red blood cell) All granulocytes (wbc) • Neutrophils • Eosinophils • Basophils One agranulocyte (wbc) • Monocyte Thrombocytes (platelets) o Lymphoid tissue (start in myeloid but end in lymphoid) One agranulocyte (wbc) • Lymphocytes Slide 6** (Figure 13.3) Pluripotent stem cell (result of a differentiated Mesenchymal cell)- Can replicate itself and replenish itself- Will differentiate into: o Myeloid ste m o Lymphoid ste m Multipotent- differentiate into a nu m b er of other blood cells, also replenish- Ex. Myeloid and lymphoid Progenitor level (blue blocks)- can only differentiate, cannot replenish- Ultimately b eco m e the adult blood cells- Don’t n e e d to know blue blocks* Proerythroblast (special process = erythropoiesis) 1 st stage- Formation of ribosomes 2 nd stage- Formation of specialized proteins called hemoglobin (becomes the dominant component of the adult rbc)- Hemoglobin carries the oxygen throughout the body- 4 Iron ato ms on the he moglobin molecules, a nd e ach carries one 3 rd stage- Reticulocyte established (immature red cell)- Nucleus is rejected- Hemoglobin re m ains along with a very s m all frag m ent of ER 4 th Stage- Mature red cell- When the Reticulocyte is released, it is still a n imm ature cell, it m atures in the blood strea m Stimulus- interrupts ho m eostasis!!!- Oxygen d elivery d ecreas es o Caused by a erobic exercise o Loss of blood (injury, diseas e)- Hypoxia = d ecre as ed levels of oxygen- REF (renal erythropoietin factor)- acts on albu min, results in the formation of erythropoitin o Goes into the blood strea m, Hem atopoiesis takes place faster o REF is s ecreted by the kidneys when a drop in oxygen is d et ected PM of rbc- All p m’s are m alleable and can chang e shap e, rbc’s p m does the sa m e, a nd doesn’t loss any of its function- Spectrin- protein that give the p m of the rbc great flexibility o Capillaries are really s m all, this allows the rbc to p ass through...
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This note was uploaded on 09/30/2011 for the course KIN 2500 taught by Professor Hargroder during the Fall '08 term at LSU.

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Test4Notes - Test 4 BLOOD Blood Functions:- Distributive o...

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