Lecture 3_Mito_Dysfunction_Aging.pptx - \u00b20\u201301\u2013 1 Lecture 3 Theories on Aging 2 Mitochondrial Dysfunction ROS KIN 3510\u2013 Physical Activity and

Lecture 3_Mito_Dysfunction_Aging.pptx - ²0–01– 1...

This preview shows page 1 - 5 out of 16 pages.

²0–01– [email protected] 1 Lecture 3: Theories on Aging 2 Mitochondrial Dysfunction & ROS KIN 3510 Physical Activity and Aging Dr. Ayesha Saleem Jan 16, 2020 Learning Outcomes What are mitochondria – structure, composition, function Mitochondrial Theory of Aging : aging caused by decline in mito function Free Radical Theory of Aging : aging caused by accumulation of oxidative stress or free radicals Describe ROS , how they are formed, the different types and how is ROSFinduced damage to proteins, lipids, carbohydrates and DNA measured? Explain the role and function of antioxidants , and list the different types of endogenous and exogenous sources Effect of exercise on ROS and mitochondria Critically evaluate research supporting the two theories of aging covered in this lecture and data that supports exerciseFbased interventions
Image of page 1
²0–01– [email protected] ² Mitochondri a Powerhouse of the cell Produce ATP (energy) Have their own DNA ( mtDNA plasmid) Electron transport chain ( ETC ) – made of 5 complexes that shuttle electrons across to ultimately make ATP and in the process utilizing oxygen Endosymbiotic theory Mitochondria and Electron Transport Chain (ETC) h ttps:// www .y o utube.c o m/ watch? v=39HTpUG1MwQ AnimalFmitochondrionFdiagram.jpg h ttps:// www .y o utube.c o m/ watch?v=VER6xW_r1vc
Image of page 2
²0–01– [email protected] Nuclear and mtDNA Nuclear DNA mtDNA Inherited from both parents Maternal … The tail of the sperm gets disintegrated which contains the mitochondria Linear Circular 3 billion base pairs (bp) 16,569 bp 20K – 25K genes 37 genes 23 pairs in each cell = 46 chromosomes 100-1000s per cell ~93% DNA is non- coding 3% is noncoding Repair and proof reading Repair and proof reading Lower mutation rate Higher mutation rate https: // diseasesF903/# I) Mitochondrial Theory of Aging Aging is caused by decline in mitochondrial function 3
Image of page 3
²0–01– [email protected] Free Radicals = ROS Free radicals have an unpaired electron(s) in the external shell of the atom or molecule. Radicals are produced by losing or accepting a single electron (LEO says GER).
Image of page 4
Image of page 5

You've reached the end of your free preview.

Want to read all 16 pages?

  • Fall '19
  • jay johnson
  • Free-radical theory, reactive oxygen species, oxidative stress, Russo G, Bulli G

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes