Chapter 21.docx - Chapter 21 Neuropathology Postmortem Studies Historically has been difficult to get tissue Differing definitions of ASD(older studies

Chapter 21.docx - Chapter 21 Neuropathology Postmortem...

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Chapter 21: Neuropathology Postmortem Studies: Historically has been difficult to get tissue - Differing definitions of ASD (older studies) - Presence of seizure disorder - Variable postmortem time to fixation - Availability of tissue (i.e. using different hemispheres) - Cause of death (i.e. hypoxia/ischemia) - Lack of adequate control groups - Differing techniques/lack of adequate description Inconsistencies in findings due to Autism Tissue Program developed by NAAR (now Autism Speaks) in 1988, now Autism Brain Net Simons Foundation, Autism Science Foundation, NIH NeuroBioBank and Gross Examination: No differences in gross examination between ASD and other groups Consistent finding across all postmortem studies Also consistent with MRI studies Gliosis Proliferation/activation of glial cells in response to injury or damage in the CNS Several studies have shown glial activation in a variety of areas of cortex and cerebellum Found in other disorders such as MS, Alzheimer’s, etc.
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