Chapter 17.docx - Chapter 17 Genetics in ASD There is a genetic component to ASD There is not a single gene for ASD Likely a combination of genetic and

Chapter 17.docx - Chapter 17 Genetics in ASD There is a...

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Chapter 17: Genetics in ASD There is a genetic component to ASD There is not a single gene for ASD Likely a combination of genetic and environmental factors that contribute to ASD Twin Studies: - Average monozygotic concordance reported in a meta-study 64% - Most have reported between 70 and 90%, with one study reporting a low rate of 37% If you have a child with ASD the chances that your 2 nd child will have ASD is 7-18% Highly heterogeneous group of genes can contribute to similar clinical presentation Specific genetic lesions can result in widely variable clinical behaviors Video: Genome – long string that forms the basis of DNA (A, T, G, C) Twin Study – if an identical twin has autism, the other twin has about an 80% chance of having autism as well Genetics is larger contributor to autism than environment Human genome is about 3 billion letters long and only about 2% codes for proteins Exome – most autism genetic studies focus on this 2%
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