LessonNo4CalciumMuscleTissueFall10(2)

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Unformatted text preview: Click to edit Master subtitle style Physiology BIO 240 Lecture No. 4 Bone Tissue Ca+2 regulation Fall 2010 Dr. Ana M Jimenez Thinking About Calcium Where can I get calcium? What is in the bones I like to chew? Where does calcium go after I eat it? Why do I need calcium? Where is Ca+2 in the body? Where does it come from? Majority of Ca+2 is in bone tissue, Least in cells - intracellular free Ca+2 is in the nanomolar range (10-9) Calcium and Phosphate Homeostasis Important hormones that maintain calcium and phosphate homeostasis in the body Calcitonin stimulates bone deposition, Secreted by C cells in thyroid gland, Decreases [Ca+2] in blood plasma, Calcitriol activated vitamin D Increases calcium and phosphate in blood plasma Parathyroid hormone stimulates bone resorption Secreted by parathyroid gland (posterior to thyroid) Increases [Ca+2] in blood plasma Estrogen stimulates bone deposition (?) Calcium and Phosphate Imbalance Chemical sensors detect level of calcium in osseous tissue, blood plasma and cells, Pathology happens during Ca+2 imbalance, Clinicians can measure levels of calcium and phosphate: in bone by measuring bone density low bone density indicates osteoporosis in blood plasma by drawing venous blood , Hypercalcemia high Ca+2 in blood >11 mg/dL, Hypocalcemia low Ca+2 in blood < 9 mg/dL, Hyperphosphatemia high phosphate >9 mg/dL, Hypophosphatemia low phosphate < 2 mg/dL Osteoporosis decreased bone density due to combination of excess bone resorption and decreased bone depostion What can you recommend for your patients who are at risk of developing osteoporosis? Physiology of Osseous Tissue Mineral Deposition by osteoblasts...
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