Lect 9 Viruses of simple euks

Lect 9 Viruses of simple euks - Le cture9 Viruse of S...

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Lecture 9 Viruses of Simple Eukaryotes
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General properties Most do not have an extracellular phase. Transmitted by cell-cell fusion as a consequence of the fungal mating process
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La France disease. Discovered in Pennsylvania, 1948. Pathology: gooey, yucky, slimy mushrooms. Infection can cause major economic impact. The first fungal virus discovered. La France isometric virus (LIV) Family: Partitiviridae dsRNA virus of Agaricus bisporus, the common mushroom. LIV genome contains nine dsRNA molecules Packaged into isometric 34 nm diameter virus particles. Three proteins of M(r) 120K, 115K and 90K known to be associated with LIV.
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Partitiviruses Virus Host species Genome size Features
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Pennicillium killing a lawn of bacteria 1952-53. Culture filtrates from Penicillium species were found to induce resistance to viral infections in mice. Interferon induction. History & Impact
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Cryphonectria parasitica = the Chestnut Blight fungus. Chestnut Blight caused by Cryphonectria (Endothia) parasitica Enters wounds, grows in and under bark Kills cambium in infected twigs, branches, and trunks
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Virus Host species Genome size Features Viruses of Cryphonectria parasitica
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The CP hypovirus . Infection with dsRNA CP hypovirus prevents orange pigment formation in the fungus. Decreases pathgenicity of the fungus. Used to save American Chestnuts EP155: Uninfected fungus G1-1: Infected fungus G2-37: Infected with viral mutant
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Timeline of discovery .
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CHV1: genome and expression 12,712 bp dsRNA genome p300
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Totiviruses
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satellites The yeast Killer virus system L (arge), M (iddle), S (mall), and X dsRNAs. Viral particle structure. 39nm, icosahedral with T = 1. Asymmetric unit is a dimer of Gag (76 kDa). 120 Gag units per viral particle, , and 1 -2 copies of the 180 kDa Gag- pol fusion protein. Small holes (10 -15A diameter) allow exit of transcripts and influx of
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Lect 9 Viruses of simple euks - Le cture9 Viruse of S...

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