ANP Lec 2 - ANP1105B 2.1 Membrane transport (pp. 63-77)...

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basic structure according to fluid mosaic model : ( fig 3.3) phospholipid bilayer - what is a phospholipid?? what do we mean when we say the hydrophilic and hydrophobic ends of phospholipids?? Why do we say fluid mosaic model?? integral membrane proteins - span PM (transmembrane); hydrophilic & hydrophobic regions; channels , carriers ANP1105B 2.1 Membrane transport (pp. 63-77) 2.1.1 Describe the structure of the plasma membrane Fig. 3.3
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http://www.biology.arizona.edu/chh/problem_sets/kidneysmetals/07t.html Phospholipid bilayer A phospholipid A phospholipid
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2.1.1.2: Associate functions with each of the following plasma membrane components: peripheral and integral membrane proteins, cytoskeleton, glycocalyx, cholesterol 1. Peripheral proteins: attached to integral proteins (usually internal side of PM); can be enzymes, involved in attachment functions, shape changes . . 2. Cytoskeleton: anchors to PM; can also interact with receptors (eg: ??) 3. Glycocalyx: ensemble of carbohydrates attached to lipids & proteins on extracellular face; “sugar coating” on PM NB: glycocalyx changes when cell becomes cancerous - can even change repeatedly to avoid recognition by immune system 4. Cholesterol: overall: reduces general membrane fluidity & stabilizes its structure – too much cholesterol causes membranes to lose flexibility Fig.
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transport enzyme activity receptors for signal transduction Fig. 3.4 intercellular joining cell-cell recognition attachment to ECM Some Functions of Plasma Membrane Proteins
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2.1.1.3: Distinguish (structurally and functionally) between: tight junctions, desmosomes, gap junctions Fig. 3.5
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fusion of adjacent plasma membranes to prevent passage of molecules why would these structures be important in the lining of the digestive tract? J. Carnegie, Uof O http://www.nastech.com/nastech/junctions_biology Fig. 3.5a 2a. Tight Junctions:
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2b. Desmosomes: anchoring junctions: molecular linking of cells to resist mechanical stress plaque linker proteins keratin filaments Where are desmosomes found? 2c. Gap Junctions: molecular channels between cells to allow passage of cytoplasmic molecules connexins electrically-excitable tissues
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2.1.1.4: List 4 functions of plasma membranes 1. selectively permeable 1. allows the cell to respond to changes in the extracellular fluid 2. site of cell-to-cell interaction and recognition http://www.bgsu.edu/departments/chem/midden/MITBCT/mem/junct.html http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Williford/assignment2_home.htm
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2.1.2 Describe and differentiate among the various types of transport across the plasma membrane selectively permeable barrier between interstitial fluid and cytoplasm hydrophobic environment a consequences for transport of water-soluble substances? interstitial fluid
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This note was uploaded on 10/03/2011 for the course ANP 1105 taught by Professor Carnegie during the Spring '08 term at University of Ottawa.

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ANP Lec 2 - ANP1105B 2.1 Membrane transport (pp. 63-77)...

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