number4 - 4) 19.3, 19.4 (370-375) A. How does a...

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4) 19.3, 19.4 (370-375) A. How does a proto- oncogene become an oncogene and what role does it play in cancer. Give a human example. B. How does a mutation in a tumor suppressor gene contribute to uncontrolled cell growth? Give an example. C. What additional mutation is found in malignant tumors? D. What is the relationship between cancer , retroviruses, and oncogenes? What is the normal, healthy function of a proto-oncogene? E. Describe the types of DNA sequences in the human genome (study fig. 19.14) A) -Oncogenes- cancer causing genes. -Proto-oncogenes -normal cellular genes that code for proteins that stimulate normal cell growth. -can turn into oncogene when there is a increase in amount of the proto-oncogene’s encoded protein or in the activity of protein. -3 ways: 1) movement of DNA within the genome -Translocating proto oncogene near an active promotor may increase amount of protein by transcribing the proto oncogene more effectively/rapidly = more proteins = caner 2) amplification of a proto-oncogene -Number of proto oncogenes in cell increase. -More proto oncogenes = more protein product = uncontrollable growth
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This note was uploaded on 10/02/2011 for the course CHEM 210 taught by Professor Clay,m during the Summer '08 term at San Mateo Colleges.

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number4 - 4) 19.3, 19.4 (370-375) A. How does a...

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