first line poc.docx - Anovulation or infertility First line Clomiphene(Selective estrogen receptor modulators or letrozole(Femara Second line Metformin

first line poc.docx - Anovulation or infertility First line...

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Anovulation or infertility First line: Clomiphene ( Selective estrogen receptor modulators) or letrozole (Femara) Second line: Metformin Metformin reduces blood sugar levels Trials found Metformin plus Clomid to be more effective than Clomid alone in ovulation induction Metformin has been found to increase ovulation and clinical pregnancy rates. it improves fertility outcomes in clomiphene citrate (CC)-resistant women Insulin resistance First line: Metformin ( Hypoglycemic agents) Management for Metabolic Risks (Insulin Resistance and Glucose Intolerance) improve insulin concentration, insulin sensitivity and serum androgen concentration reduction in LH and an increase in SHBG concentration ( Sex hormone-binding globulin ) Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of sex steroid hormones. decrease premenopausal syndrome in PCOS patients
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