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Ch06 - About VPHY3100 Carefully read Dr Li's"About VPHY3100...

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Wells/VPHY3100 About VPHY3100… Carefully read Dr. Li’s “About VPHY3100” PPT! My contact information Dr. Wells [email protected] 706-202-8715 Room 2216 Vet Med Bldg My PPT lectures will be available on eLC at least 24 hours in advance You are responsible for reading each chapter prior to the first lecture associated with that chapter My office hours By appointment Email me well in advance to schedule an appointment Available (in Room 363) for ~10 minutes before class and ~ 5 minutes after class
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Wells/VPHY3100 About VPHY3100… Complete, sign, and hand in your Quiz Form (available on eLC) no later than the end of this week! Pop quizzes will occur at the end of the class period. Bonus points from quizzes will NOT count unless your Quiz Form has been submitted this week. There will be absolutely no make-up quizzes.
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Wells/VPHY3100 About VPHY3100… Rain Check Policy Some questions are “rain checks”, but others are not Please raise your hand Rain check = 8.5 x 11 sheet of paper with date, question, answer, and my signature (get at end of class) Retain your rain check until the end of the semester Only one rain check per student per semester
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CHAPTER 6: Interactions Between Cells & the Extracellular Environment K. Wells VPHY3100: Elements of Physiology Dept. Physiology & Pharmacology College Vet. Med.
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Wells/VPHY3100 Lecture outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling
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The cell FIGURE 3.1
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Wells/VPHY3100 The cell: inside & out The cell Cytoplasm Cytosol Organelles Nucleus Cell (or plasma) membrane The extracellular space FIGURE 3.2 Inside of cell Outside of cell
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Wells/VPHY3100 Lecture outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling
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Wells/VPHY3100 The extracellular environment The cell membrane acts as a physical barrier between the cytoplasm (inside of the cell) and the extracellular fluid (ECF, outside of the cell) Living organisms are ≥ 70% water by weight! Total body water is divided between: Intracellular compartments (~67%) Extracellular compartments (~33%) 20% as vascular fluid (blood plasma) 80% as interstitial fluid (non-vascular “tissue fluid” that resides within the extracellular matrix)
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Wells/VPHY3100 Extracellular & intracellular compartments FIGURE 14.8
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The extracellular environment The extracellular environment includes everything that lies outside of cells The ECM, or extracellular matrix: Gel-like hydrated material “Ground substance” Glycoproteins (such as integrins) Proteoglycans Protein fibers Collagen Elastin
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Selective permeability of cell membranes Simple diffusion Carrier- mediated transport Lodish et al., Molecular Cell Biology, 5th Ed.
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