Exam4_Summer09_Key

Exam4_Summer09_Key - GENE 3200 Summer 2009 Bedell Exam 4...

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GENE 3200 – Summer 2009 – Bedell Exam 4 – July 20 ID no. 810_________ KEY ___________ 1 Write your ID number (810 number, NOT SSN) on every page . Write your initials on the first page only . All of the multiple choice questions have only one correct answer. The exam should be completed in ink. Regrades will not be given if you write in pencil. All requests to re-grade an exam must be made in writing to Dr. Bedell within 48 hours of the grades being posted on WebCT. By accident this exam totals 101 points. So the pts wrong were deducted from 101, not 100. 1. (2.5 pts) The first level of compaction of DNA consists of A. DNA winding around histones to form nucleosomes. B. tight coiling of DNA with nucleosomes into higher order structures. C. high level compaction into metaphase-type chromosomes. D. histone, DNA, and nonhistone covalent bonding. 2. (2.5 pts) At what stage of mitosis are chromosomes compacted 250-fold over the 40-fold compacted 300Å fiber? A. prophase D. telophase B. metaphase E. never achieves this level of compaction C. anaphase 3 (1 pt) True or false . The base of a chromatin loop that anchors it to the scaffold is an ARS. 4. (2.5 pts) During mitosis, kinetochores develop during____________________. A. telophase. D. metaphase. B. anaphase. E. prophase. C. interphase F. they form only in meiosis, not in mitosis 5. A specific chromosome of yeast is shown on the left panel below, with the centromere as the circle and the two telomeres labeled (Tel). For each end of the chromosome, restriction sites for Bam HI are shown with the positions of two probes (L and R) and the size (in Kb) of the DNA from the telomere to the restriction site. (Note that the size of the chromosome is not drawn to scale). To the right is a Southern blot of Bam HI digested DNA using probe L with five possible results shown in lanes A – E. 5 (cont). (2.5 pts) Which of the lanes represent a result that is most likely to occur with yeast that are mutated in the telomerase gene? A. Lane A D. Lane D B. Lane B E. Lane E C. Lane C F. None of these
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GENE 3200 – Summer 2009 – Bedell Exam 4 – July 20 ID no. 810_________ KEY ___________ 2 6. (1 pt) True or false. Many human tumor cells have the capacity to divide indefinitely because of abnormal activation of the telomerase gene. 7. (1 pt) True or false . Euchromatin is generally transcriptionally inactive . 8. (2.5 pts) Which of the following would be expected to disrupt chromosome segregation? A. A mutation in the gene encoding cohesin B. A mutation in the gene encoding kinetochore proteins C. A mutation in the gene encoding motor proteins required for movement on the spindle D. A mutation in the DNA sequence of a centromere E. All of the above 9. (2.5 pts) What is the basis for position effect variegation? A.
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Exam4_Summer09_Key - GENE 3200 Summer 2009 Bedell Exam 4...

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