LW_BCH4122Lecture5_2011Sep

LW_BCH4122Lecture5_2011Sep - Stem Cells Lisheng WANG...

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Stem Cells Lisheng WANG lwang@uottawa.ca Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
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Lecture 5. Adult stem cells (continue) and Application Embryonic hematopoiesis (continue) Application of adult stem cells HSC Disorders of hematopoiesis Application of HSC Limbal stem cells (eye) MSC Neural stem/progenitor cells Cardiac progenitors
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(Source of image: http://www.paterson.man.ac.uk/images/groups/scbio1.jpg) (Aorta-Gonado- Mesonephros) Embryonic Hematopoiesis Mouse
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The latest findings regarding the source of HSC during mouse embryonic development Embryonic Hematopoiesis Nature 446 , 996 - 997 (2007). J Cell Biochem. 2009 Jul 1;107(4):586-91 Previous theory Current theory
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Summary of Embryonic hematopoiesis - Mouse Previous theory: The yolk-sac-derived, primitive blood-forming cells are transient and die; all the adult HSC (blood-forming cells) originate from the AGM around E10.5. Current theory: at least some adult HSCs come from the yolk sac (contrary to the view that yolk-sac and intra-embryonic haematopoiesis are completely separated in mammals) Embryonic Hematopoiesis Nature 446 , 996 - 997 (2007). & Nature 446, 1056–1061 (2007). J Cell Biochem. 2009 Jul 1;107(4):586-91
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Embryonic hematopoiesis – limited studies using human embryo Limited research with human embryos has shown that human hematopoie tic cell clusters arise from the AGM region between the 27th and 40th day of human development, through an intermediate blood-forming endothelium stage Embryonic Hematopoiesis Development 1999;126: 793-803; Blood 1996; 87: 67-72. Immunity 2001; 15: 487-495
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Embryonic Hematopoiesis Embryonic hematopoiesis – studies using human embryonic stem cells
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Embryonic Hematopoiesis Embryonic hematopoiesis – studies using human embryonic stem cells
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Lecture 5. Adult stem cells (continue) and Application Embryonic hematopoiesis (continue) Application of adult stem cells HSC Disorders of hematopoiesis Application of HSC Limbal stem cells (eye) MSC Neural stem/progenitor cells Cardiac progenitors
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1. Polycythemia Vera (PV): Excessive production of mature red cells (sometimes also platelets and granulocytes). It may lead to, among other things, increased blood viscosity, headaches, strokes and myocardial infarcts 2. Essential Thrombocytosis (ET): Overproduction of abnormal platelets resulting in bleeding and thrombosis Both diseases are caused by V617F mutation in the JAK2 protein involved in EPO and TPO signaling, which results in its constitutive activation Hematological diseases associated with abnormal hematopoiesis Disorders of Hematopoiesis
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Hematological diseases associated with abnormal hematopoiesis 3. Chronic Myelogenous Leukemia (CML): Dysregulated proliferation of a single HSC and its progeny leading to excessive production of relatively normal granulocytes. Caused by 9:22 translocation leading to
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LW_BCH4122Lecture5_2011Sep - Stem Cells Lisheng WANG...

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