Lack of Camp-response Element-binding Protein 1 -2

Lack of Camp-response Element-binding Protein 1 -2 - Lack...

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Unformatted text preview: Lack of cAMP response element-binding protein 1 in the Hypothalamus Results in Obesity By: Sara Temkit Date: September 12, 2011 Background CREB proteins are transcription factors bind to certain sequences called cAMP response elements (CRE) in DNA CREB: cAMP response element-binding Background Increase/ decrease the transcription of certain genes. highly related (in structure and function) to CREM (cAMP response element modulator Background CREB1 is part of the Melanocortin system in the hypothalamus. Functions of Melanocortin system: Controls food intake and energy expenditure Key player: membrane-bound Melanocortin-4- receptor (MC4R) in Paraventricular nucleus (PVN) Background Postulated Pathway(in vivo):- MC4R signals through Gs- Activates adenyl cyclase- PKA phosrylates CREB1 and leads to its activation- CREB1 recruits co-activator complex and increases CREB1 target gene expression Hypothesis: - CREB1 mediates the downstream genomic Background CREM1 vs. CREB1 CREM is up-regulated when CREB1 is deleted CREM1 and CREB1 have overlapping yet distinct roles in regulatinggene expression Melanocortin Pathway Transcription product will be translated into protein by ribosomes. ribosomes....
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This note was uploaded on 10/09/2011 for the course BCH BCH4101 taught by Professor Dr.sener during the Spring '11 term at University of Ottawa.

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Lack of Camp-response Element-binding Protein 1 -2 - Lack...

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