bio lecture 7. DNA

bio lecture 7. DNA - DNA Dr Mark Holbrook MACROMOLECULES OF...

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1 DNA Dr. Mark Holbrook MACROMOLECULES OF THE CELL Polysaccharides Proteins (polypeptides) Lipids Nucleic acid (polynucleotides) DNA • D eoxyribo n ucleic a cid DNA as genetic material Structure of DNA DNA model
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2 What Known (< 1945) Biological variation as hereditary “factors” Traits are determined by factors (aka genes) Genes are located on chromosomes Chromosomes are DNA and protein 12.3 African blood lily, late prophase Essential Properties of Genes Contain information Can be replicated precisely (almost) Can produce observable traits Genetic Material: Protein or DNA? • Protein was known to be a macromolecule with: o great heterogeneity o specific function • DNA structure and function was little known and seemed too uniform to account for observed variation
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3 Evidence Supporting DNA as the Genetic Material Bacterial transformation o (Griffith, Avery, McLeod, McCarty: read text) o DNA was the heritable material Bacteriophage infection Bacteriophage T2 A protein coat enclosing a single thread of DNA. Infects E. coli bacteria Bacteriophage Infection Bacterial cell Phage head Tail sheath Tail fiber DNA 16.3 (protein) (protein) Bacteriophage have traits: placque morphology, host range, etc.
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4 Following Protein and DNA • Sulfur (S) is present in proteins (but generally not in DNA)
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This note was uploaded on 10/11/2011 for the course BIO 010 taught by Professor Holbrook during the Spring '11 term at Iowa State.

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bio lecture 7. DNA - DNA Dr Mark Holbrook MACROMOLECULES OF...

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