bio lecture 11. mutation

bio lecture 11. mutation - Mutation Dr. Mark Holbrook...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Mutation Dr. Mark Holbrook Mutation Definition Mutagens Effects of mutation Changes in DNA Defenses (e.g., proofreading, repair) Mutation Changes in the genetic material: Chromosome changes: o 50% of spontaneous human abortions o Down syndrome (extra chromosome 21) Smaller changes in DNA: o Uncorrected errors in replication o Caused by mutagens
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Mutagens (agents that generate mutations) Radiation that reacts with DNA: X-rays, cosmic rays Ultraviolet light Chemicals: Analogs of nucleotide bases Intercalators (insert into and distort DNA) Agents that damage (oxidize) bases Agents in cigarette smoke 3 rd -hand smoke (on surfaces) causes disease Sleiman et al 2010 PNAS; 107(15):6576-81. The effects of mutation (1) Mutations cause changes in DNA Altered product Function altered or absent Biological consequences depend upon normal function of the product: o Non-vital o Vital (essential) The effects of mutations (2) Somatic cells vs. germ cells o Mutations in somatic cells Disease (e.g., cancer)
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/11/2011 for the course BIO 010 taught by Professor Holbrook during the Spring '11 term at Iowa State.

Page1 / 8

bio lecture 11. mutation - Mutation Dr. Mark Holbrook...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online