LECTURE 17 Cell Communication

LECTURE 17 Cell Communication - 3 G PROTEIN COUPLED...

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9/20/11 1 LECTURE 17 CELL COMMUNICATION WHAT IS BEING COMMUNICTED ? Chemical signaling may be Short range (paracrine) Long range (hormonal)
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9/20/11 2 CELL COMMUNICATION REQUIRES 3 PROCESSES Reception Transduction Response RECEPTION REQUIRES A LOCK AND KEY INTERACTION BETWEEN THE CHEMICAL SIGNAL AND A PROTEIN RECEPTOR Individual cells respond to a limited set of signals for which they have receptors A single cell may have 10 to 100,000 different receptors Many signals acting together can elicit different cellular responses - a complex network MOST RECEPTORS ARE CELL SURFACE TRANSMEMBRANE PROTEINS G Protein Coupled Receptors Receptor Tyrosine Kinases Chemical Dependent Ion Channels
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9/20/11
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Unformatted text preview: 3 G PROTEIN COUPLED RECEPTORS RECEPTOR TYROSINE KINASES CHEMICAL DEPENDENT ION CHANNELS 9/20/11 4 SOME SIGNAL RECEPTORS ARE CYTOPLASMIC PROTEINS SIGNAL TRANSDUCTION IS THE PROCESS BY WHICH THE EFFECTS OF THE EXTRACELLULAR SIGNAL ARE CHANGED INTO INTRACELLULAR CHANGES THE CLASSICAL EXAMPLE OF A SECONDARY MESSENGER IS CYCLIC AMP 9/20/11 5 THERE ARE MANY DIFFERENT WAYS IN WHICH A CELL CAN RESPOND TO A SIGNAL • MANY OF THESE ARE ESSENTIAL FOR THE FORMATION, MAINTENANCE OF STRUCTURE AND PROPER FUNCTION OF THE MULTICELLULAR AGGREGATES MANY CELL RESPONSES REQUIRE CHANGES IN GENE EXPRESSION THE CHEMICAL NATURE OF CELL COMMUNICATION MAKES IT A GOOD TARGET FOR PHARMACOLOGICAL MANIPULATION...
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This note was uploaded on 10/11/2011 for the course BIO 010 taught by Professor Holbrook during the Spring '11 term at Iowa State.

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LECTURE 17 Cell Communication - 3 G PROTEIN COUPLED...

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