cs_9_Fall2011_class_slides [Compatibility Mode]

cs_9_Fall2011_class_slides [Compatibility Mode] - Unit 9...

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Unit 9 Ligand Binding CHEM 4:012 Fall 2011 1 Announcements Check scores on ICON: Topic 7, Exam 1, prelecture unit 1, and discussion weeks 1, 2, 3, 4, and 5) Regrades should be turned in to your TA during lab time CHEM 4:012 Unit 9 Case Study Biomolecules and Equilibrium Binding Hemoglobin Structure Secondary structure: 75% is α -helical Tertiary structure: a subunit containing 1 heme group Quaternary structure: 4 subunits per hemoglobin Molecular weight: 68000 g/mol per hemoglobin (17000 g/mol per subunit)
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Unit 9 Ligand Binding CHEM 4:012 Fall 2011 2 Heme Molecular Structure Fe 2+ in center of heterocyclic ring porphyrin Fe 2+ bound to 4 nitrogens in the porphyrin FYI: an iron heme is also at the active site of catalase. Body Basics Hemoglobin blood protein Adults: 12-18 g/100 mL exchanges O 2 2 in the lungs and body tissues Myoglobin muscle protein stores O 2 for later use by muscle cells heart contains 0.1% ARTERIES VEINS TISSUES LUNGS Oxyhemoglobin Deoxyhemoglobin CO 2 O 2 CO 2 O 2 HCO 3 - Fe Fe Fe Fe Fe Fe Fe Fe NHCOO - NHCOO - O 2 O 2 O 2 O 2 Fe Myoglobin Body Basics Series of equilibria Oxyhemoglobin 4 O 2 transported pH change triggers release of O 2 Deoxyhemoglobin Transports (some) CO 2 CO 2 bound to protein not heme ( Carbonic anhydrase- a zinc containing enzyme, does most of the work) ARTERIES VEINS TISSUES LUNGS Oxyhemoglobin Deoxyhemoglobin CO 2 O 2 CO 2 O 2 HCO 3 - Fe Fe Fe Fe Fe Fe Fe Fe NHCOO - NHCOO - O 2 O 2 O 2 O 2 Fe Myoglobin
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Unit 9 Ligand Binding CHEM 4:012 Fall 2011 3 Ferrohemoglobin•O 2 Binding Myoglobin binding O 2 is relatively simple:
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cs_9_Fall2011_class_slides [Compatibility Mode] - Unit 9...

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