LAST QUIZ PROBLEMS

LAST QUIZ PROBLEMS - your knowledge in general and/or...

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Biology 313: Problem Set (This is the 12 th 10 point “quiz”) (12/6/2010) Name: _______________________________ (10 points) WORK IN GROUPS IF YOU LIKE!!!! Read the paper by Wolfe-Simon et al. in Science (A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus); a pdf of this paper is in the “Quizzes” folder of Bio. 313. After you’ve digested the paper, answer the following questions. 1. What is the basic finding of this paper? Given what you’ve learned in Bio 313 (and other Bio courses), is this a startling finding, something you will be discussing over the dinner table when you go on Winter break? 2. What are the chemical similarities/dissimilarities between As and P? Arsenic is usually toxic, but why isn’t P? To answer these questions might require that you utilize
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Unformatted text preview: your knowledge in general and/or organic chemistry. 3. Would you predict that DNA containing As rather than P could bind histones? Why or why not? 4. Assume that As is substituted for P in the backbone of DNA in the GFAJ-1 strain. Draw the structure of a polynucleotide DNA strand in the bacterium (using 3 nucleotides of your choice). Could hydrogen bonding occur? Di-ester bond formation? This might require that you utilize your knowledge of general and/or organic chemistry. 5. Would you predict that DNA containing As rather than P could undergo semi-conservative replication? Why or why not? 6. Why is P rather then As present in most biomolecules? Why doesn’t our DNA have As rather then P?...
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This note was uploaded on 10/06/2011 for the course BIO 313 taught by Professor Rodermel during the Spring '11 term at Iowa State.

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LAST QUIZ PROBLEMS - your knowledge in general and/or...

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