Lecture 1 Exam 3

Lecture 1 Exam 3 - Biology 313 Lecture 23 Oct 20, 2010...

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Unformatted text preview: Biology 313 Lecture 23 Oct 20, 2010 Problems with Genetic Mapping Methods cM do not correspond precisely to Kbp along a DNA strand Why? Crossing over rates vary depending on chromosome, species, sex hotspots of recombination: regions of chromosome where RF is 10X higher than elsewhere in the genome Humans: ~25-50K of these hotspots!! Physical Mapping Methods Deletion Mapping Somatic Cell Hybridization DNA Sequencing: the most direct way Deletion Mapping Chromosomal Deletions: often occur due to mutagens (e.g., X-ray): can be very large and very small Sometimes the deleted part of the chromosome becomes stuck to the end of another chromosome (called a translocation ), or it can become lost during mitosis or meiosis Sectoring in immutans (Arabidopsis) is caused by a small X-ray induced deletion in a nuclear gene White = phytoene (converted to red via Enzyme A on exam) Example of an X-ray mutation Half of the progeny show the mutant phenotype All of the progeny are normal phenotype Deletion mapping problems (end of Ch 7) Worked problem #4 Application question #32 THESE ARE FUN PUZZLES Mouse-human Hybrid cell Mouse +...
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This note was uploaded on 10/06/2011 for the course BIO 313 taught by Professor Rodermel during the Spring '11 term at Iowa State.

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Lecture 1 Exam 3 - Biology 313 Lecture 23 Oct 20, 2010...

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