Lecture 3 Exam 3

Lecture 3 Exam 3 - Biology 313 Lecture 25 Oct 25, 2010...

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Biology 313 Lecture 25 Oct 25, 2010
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Rearrangements -Change structure of chromosome -4 types of rearrangements: Duplications Deletions Inversions Translocations
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Translocations
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N1 & T1 are homologous centromeres and want to move toward opposite poles; same for T2 and N2
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Robertsonian Translocation Long arms of two acrocentric chromosomes become joined to a common centromere through a translocation to form: - a metacentric chromosome with two long arms - a short chromosome with two very short arms (becomes lost during meiosis) Robertsonian translocations are named for the American insect geneticist W.R.B. Robertson
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Robertsonian Translocations 1/ 900 babies is born with a Robertsonian translocation, making it the most common kind of chromosome rearrangement known in people All five human acrocentric chromosomes -- 13, 14, 15, 21 and 22 -- engage in Robertsonian translocations Most frequent Robertsonian translocation: -between 14 and 21 (Familial Down Syndrome)
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Translocations shape genomes during evolution A Robertsonian Translocation occurred in a human ancestor: large metacentric chrom 2 + short chromosome (lost)
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Chromosome mutations Variations in number and/or structure of chromosomes Three classes: Rearrangements Aneuploids Polyploids
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This note was uploaded on 10/06/2011 for the course BIO 313 taught by Professor Rodermel during the Spring '11 term at Iowa State.

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Lecture 3 Exam 3 - Biology 313 Lecture 25 Oct 25, 2010...

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