{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Receptors11Slides - Receptors Francis Schlemmer Ph.D R.Ph...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Receptors Francis Schlemmer, Ph.D., R.Ph. BPS360 August 22, 2011
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Reading Assignment Katzung BG et al ., Basic and Clinical Pharmacology , 11 th Ed, 2009, Chapters 1 and 2, McGraw Hill.
Background image of page 2
Objectives Following this lecture, students should be able to: Understand the general concepts of pharmacology, drug action, and drug sources. Identify the differences between drug effect and drug action; and receptor selectivity and specificity. Characterize the types of chemical bonds that drugs form with receptors. Compare drug potency and efficacy using dose- response curves. Distinguish between drug affinity & intrinsic activity. Differentiate the actions of agonists vs. antagonists. Define TD50, LD50 & therapeutic index (TI).
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
What is Pharmacology? Pharmacology is the study of substances ( drugs ) that interact with living systems through chemical processes. Pharmacodynamics Mechanisms of action & drug effects “What the drug does to the body” Pharmacokinetics Drug absorption, distribution, metabolism & excretion “What the body does to the drug”
Background image of page 4
Drug Sources Naturallly-occuring (Natural Products) Cocaine (from coca leaves) Paclitaxel (from bark of Pacific Yew) Semi-synthetic Heroin (from Poppy seeds) Methscopolamine (from Jimson weed) Synthetic Fentanyl Hydrochlorthiazide
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Viewing the Levels of Drug Action Molecular Cellular Tissue System
Background image of page 6
Molecular Targets of Drugs Neurotransmitter receptors Hormone receptors Enzymes Carrier molecules Ion channels Idiosyncratic targets Nucleic acids
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
How Drugs Work Drugs increase or decrease normal
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}