Receptors11Slides

Receptors11Slides - Receptors Francis Schlemmer, Ph.D.,...

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Receptors Francis Schlemmer, Ph.D., R.Ph. BPS360 August 22, 2011
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Reading Assignment Katzung BG et al ., Basic and Clinical Pharmacology , 11 th Ed, 2009, Chapters 1 and 2, McGraw Hill.
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Objectives Following this lecture, students should be able to: Understand the general concepts of pharmacology, drug action, and drug sources. Identify the differences between drug effect and drug action; and receptor selectivity and specificity. Characterize the types of chemical bonds that drugs form with receptors. Compare drug potency and efficacy using dose- response curves. Differentiate the actions of agonists vs. antagonists. Define TD50, LD50 & therapeutic index (TI).
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What is Pharmacology? Pharmacology is the study of substances ( drugs ) that interact with living systems through chemical processes. Pharmacodynamics “What the drug does to the body” Pharmacokinetics Drug absorption, distribution, metabolism “What the body does to the drug”
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Drug Sources Naturallly-occuring (Natural Products) Cocaine (from coca leaves) Paclitaxel (from bark of Pacific Yew) Semi-synthetic Heroin (from Poppy seeds) Methscopolamine (from Jimson weed) Synthetic Fentanyl Hydrochlorthiazide
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Viewing the Levels of Drug Action Molecular Cellular Tissue System
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Molecular Targets of Drugs Neurotransmitter receptors Hormone receptors Enzymes Carrier molecules Ion channels Idiosyncratic targets Nucleic acids
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How Drugs Work Drugs increase or decrease normal
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This note was uploaded on 10/07/2011 for the course PHYB 301 taught by Professor Staff during the Fall '08 term at Ill. Chicago.

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Receptors11Slides - Receptors Francis Schlemmer, Ph.D.,...

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