Antibiotic Dosing in Renal Replacement Therapy.doc -...

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Antibiotic Dosing in Renal Replacement Therapy 13/5/11 - there is little published data to guide dosing of antibiotics in RRT and the critically ill. - therefore we must use first principles and utilize therapeutic drug monitoring if available. - things to consider: Properties of the antibiotic - size of molecule - charge - solubility Pharmaokinetics of drug - how much will be dialysed - Vd - clearance - protein binding Pharmacodynamics of drug - what concentrations need to be achieved to be effective - kill characteristics of drug: - peak dose/concentration dependent (aminoglycosides)

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