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DNA - Download 8 DNA Structure and Replication Principles...

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Download 8 DNA Structure and Replication Principles of Biology BIOL 1543 Greig Roberts, DDS Office: SCEN 417 E-Mail: [email protected]
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2 The monomers of nucleic acids are nucleotides composed of a sugar, phosphate, and nitrogenous base The sugar and phosphate form the backbone for the nucleic acid or polynucleotide Sugar OH O P O O - CH 2 H O H H OH H H N N H N N H H H N Phosphate group Nitrogenous base Nucleotide monomers Sugar-phosphate backbone T G C T A Nucleotide
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3 DNA polynucleotide A C T G T Sugar-phosphate backbone Phosphate group Nitrogenous base Sugar A C T G T Phosphate group O O O O P CH 2 H 3 C C C C C N C N H H O O C O O H C H H H C H Nitrogenous base (A, G, C, or T) Thymine (T) Sugar (deoxyribose) DNA nucleotide DNA nucleotide DNA and RNA are polymers of nucleotides DNA is a nucleic acid made of long chains of nucleotide monomers.
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4 DNA has four kinds of nitrogenous bases: A, T, C, and G C C C C C C O N C H H O N H H 3 C H H H H N N N H O C H H N H C N N N N C C C C H H N N H C C N C H N C N H C O H H Thymine (T) Cytosine (C) Adenine (A) Guanine (G) Purines Pyrimidines DNA and RNA are polymers of nucleotides
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5 RNA is also a nucleic acid, but has a slightly different sugar. RNA uses U instead of T (the other 3 bases are same) Nitrogenous base (A, G, C, or U) Phosphate group O O O O P CH 2 H C C C C N C N H H O O C O O H C H H O H C H Uracil (U) Sugar (ribose) Key Hydrogen atom Carbon atom Nitrogen atom Oxygen atom Phosphorus atom DNA and RNA are polymers of nucleotides
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6 DNA is a double-stranded helix James Watson and Francis Crick worked out the three-dimensional structure of DNA, based on work by Rosalind Franklin.
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