Drugs - Lecture 7 Drugs Principles of Biology BIOL 1543...

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Lecture 7 Drugs Principles of Biology BIOL 1543 Greig Roberts, DDS Office: SCEN 417 E-Mail: groberts@uark.edu
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2 Enzyme Activity Can Mirror Drug Action The way enzymes (and enzyme-inhibitors) act can give us a clue as to how our medicines work Enzymes are protein catalysts that accelerate specific chemical reactions but does not itself undergo net chemical changes
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3 Substrate Enzyme Active site Normal binding of substrate Enzyme inhibition Noncompetitive inhibitor Competitive inhibitor Enzyme inhibitors block enzyme action A competitive inhibitor takes the place of a substrate in the active site. A noncompetitive inhibitor alters an enzyme’s function by changing its shape.
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4 Feedback inhibition regulates cell activity In feedback inhibition (AKA Negative feedback) , a reaction’s product blocks the reaction itself. This is a mechanism to regulate metabolism in cells. It saves resources from being wasted in reducing unnecessary production. And controls the action being produced so that it does not progress too extremely
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This note was uploaded on 10/14/2011 for the course BIOL 1543 taught by Professor Roberts during the Spring '08 term at Arkansas.

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Drugs - Lecture 7 Drugs Principles of Biology BIOL 1543...

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