refer3 - To understand the molecular mechanisms involved in...

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To understand the molecular mechanisms involved in the effect of exercise training, we examined hepatic transcriptional profiles using cDNA microarrays in exercise -trained and untrained mice with diet-induced obesity. C57BL/6J male mice (n = 10/group) were fed with a normal diet, high-fat diet (HFD), or HFD with exercise training for 12 weeks. The expression level of ≈10,000 transcripts in liver tissues from each group was assessed using cDNA microarray analysis. Exercise training improved lipid profiles and hepatic steatosis and decreased body fat mass induced by the HFD. Seventy-three genes were differentially expressed in the HFD- and/or HFD with exercise training-treated groups, compared with the normal diet- and HFD-fed groups, respectively. Interestingly, the expression profiles involved in metabolism, such as elongation of very long chain fatty acids-like 2, lipin, and malic enzyme, were changed by exercise training. In addition, expression of genes altered by exercise training related to defense and stress response, including metallothionein 1 and 2 and heat shock protein, showed interesting findings. Our study showed beneficial effects of exercise training in preventing the development of obesity and metabolic disorders in mice with diet-induced obesity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) Lee, K., Kim, S., Cha, Y., So, J., Park, J., Kang, K., et al. (2006). Effect of Exercise on Hepatic Gene Expression in an Obese Mouse Model Using cDNA Microarrays. Obesity , 14 (8), 1294- 1302. doi:10.1038/oby.2006.147. Skeletal muscle responds to endurance exercise via increased transcription of metabolic and stress-related genes ultimately to yield increased steady-state levels of specific proteins. These changes in transcriptional activity are highly dependent on the mode, duration, intensity and frequency of the contractile stimulus. One of the major challenges for exercise physiologists over the coming decades is to identify the exercise 'signal(s)' that are responsible for initiating the adaptive response and the precise signal transduction pathways which mediate the adaptive processes. In this regard, it is now becoming apparent that cellular energy status may have an important role to play in this process. For example, many stress-and metabolic-related
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This note was uploaded on 10/16/2011 for the course PSYCH 101 taught by Professor Brown,b during the Spring '08 term at BYU.

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refer3 - To understand the molecular mechanisms involved in...

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