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4 - Cardiovascular responses to sympathomimetics...

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Cardiovascular responses to sympathomimetics Phenylephrine Isoproterenol Cardiac Contractility ↑↑↑ ↑↑↑ Heart rate ↓↓ vagal or ↑↑↑ Cardiac output ↑↑ Blood pressure Diastolic ↑↑ ↓↓ Systolic ↑↑ ↑↑ a Small does decrease, large doses increase Norepinephrine ↑↑ No beta-2
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Mechanisms for control of cardiac output 1. Autonomic control Heart Blood vessels 2. Reflex autonomic control Heart Blood vessels 3. Renin-Angiotensin system Blood vessels 4. Local control Blood vessels
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Dr. Irvine H. Page Eli Lilley renin + isolated perfused dog tail = NO RESPONSE Angiotonin renin + isolated perfused dog tail + plasma = vasoconstriction Discovery of the Renin-Angiotensin System Cross circulation exp. b/t donor hypertensive dog and nephrectom. recipient dog Dr. Eduardo Braun-Menendez Univ. of Buenos Aires Hypertensin ANGIOTENSIN II U of M Research Conf.
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