Final Exam Lecture 10

Final Exam Lecture 10 - Lecture 10 April 5, 2005 This is...

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Lecture 10 April 5, 2005 This is the first day of notes for the final. RENAL PHYSIOLOGY I Today: Lecturer: TylerRork rork@biology.rutgers.edu Room: B 219 Nelson Labs Read in Text: pg. 585-590; 624-625 Renal Morphology Nephron : basic functional unit of the kidney, filters plasma, 1 million nephrons/ kidney Medulla (inner layer) and cortex (outer layer) Bowman’s capsule : beginning of renal tubules Juxtaglomerular apparatus (JGA) : where distal tubules pass b/n efferent and afferent arterioles Peritubular capillaries and vasa recta : blood vessels around the nephron Basic Renal Functions Filtration : flow of protein and cell-free plasma (filtrate) from the glomerular capillaries into Bowman’s capsule Reabsorption : selective transport of molecules from the lumen of the renal tubules to the interstitial fluid outside tubules Secretion : selective transport of molecules from the interstitial fluid outside tubules to the lumen of the renal tubules Excretion : elimination of materials from the body in the form of urine Fig 19.7 At the glomerulus , plasma is filtered into Bowman’s capsule Reabsorption and secretion occur between peritubular capillaries and the renal tubules Exctretion: renal tubules collecting ducts minor calyx major calyx renal pelvis ureter bladder urethra elimination from body Fig 19.8 Direction of blood flow: afferent arteriole glomerulus efferent arteriole Podocytes : specialized epithelial cells on the glomerular capillaries Have long foot processes that wrap around the capillary Bowman’s space : space between the glomerulus and the walls of Bowman’s capsule Glomerular membrane: The glomerular filtration barrier has 3 parts Capillary endothelium : may have large gaps (fenestrations) for water and ions to pass Basement membrane : shared by podocytes and capillary endothelial cells Podocyte foot processes
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Only very small substances (Na, Cl, glucose, water) can pass through all 3 barriers Excluded substances: . Excluded substance are not found in Bowman’s space Glomerular filtration based on Starling forces: 4 pressures involved Hydrostatic Pressures Glomerular capillary hydrostatic pressure (P GC ) = ~60mmHg Is the blood pressure in the glomerular capillaries Favors filtration since there is positive blood pressure in the glomerulus that tends to push filtrate out of capillaries into Bowman’s space Bowman’s capsule hydrostatic pressure (P BC ) = ~15mmHg Comes from Bowman’s capsule fluid that just got filtered out Opposes filtration since this pressure tends to push filtrate back into glomerulus
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Final Exam Lecture 10 - Lecture 10 April 5, 2005 This is...

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