Lecture 26 - Kin 110Lecture #26 Monday April 12th, 2010...

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Kin 110—Lecture #26 Monday April 12 th , 2010 Components of Blood Red blood cells: transport oxygen o Deliver oxygen from lungs to other tissues in the body o To do this, red blood cells contain HEMOGLOBIN . White blood cells: immune system Platelets: cell fragments that aid blood clotting Plasma: the fluid portion of the blood Red Blood cells- 41-46% of total blood volume o Women: 41-44% o Men: 43-46% Hemoglobin: o A complex protein that is a single proteins (“globin”) with the iron in the center (“heme”) Red Blood Cell Synthesis: o Occurs in the bone marrow o 2 events: Synthesis of heme Cell division o Need iron, B6, copper, zinc, amino acids, DNA o Folate (B9) and B12 in the right quantities Scenario #1: DNA synthesis is too slow, and the cells do not divide enough times that it = large red blood cells that break easily which lead to macrocytic (big cell) anemia. Anything that interferes with DNA synthesis will cause macrocytic anemia. E.g.: Folate Scenario #2: Heme synthesis is too slow, and then the cells divide too many times. Small, pale cells without enough hemoglobin=macrocytic (small cell) anemia Anything that interferes with heme synthesis causes macrocytic anemia E.g.: low iron, zinc copper, B6 or too much lead Any type of anemia interferes with transport of oxygen Without adequate oxygen transport, cells less able to get energy from oxidative sources.
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Lecture 26 - Kin 110Lecture #26 Monday April 12th, 2010...

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