Psyc404 Teacher's Notes

Psyc404 Teacher's Notes - LECTURE 1 INTRO: Principles of...

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LECTURE 1 INTRO: Principles of Behavioral Pharmacology “There’s always wan encouragin’ thing about th’ sad scientific facts that come out  ivry week in th’ pa-apers.  They’re usually not thrue.” - Finley Peter Dunne, 1919 Introduction: There are 3 interrelated characteristics which define any field  of inquiry.   1. What is the basic question which the field attempts to answer?   With regard to behavioral pharmacology there are 2 answers to question 1  depending upon which initial approach is taken to the problem. a. Behavior  first.  What are the neurochemical substrates of behavior  which can be elucidated by the specific effects of drugs? b. Drugs  first.  What are the behavioral effects of drugs and how is  this related to their chemical actions?  And as a corollary, of what therapeutic  potential are these actions? 2. What  techniques  are used to find such answers?  Much more than we  like to admit, techniques really limit the questions that we can ask.  Just  think what questions we could suddenly address after the invention of the  microscope or the telescope. With regard to the second question the answer would seem quite straightforward;  the tool in this case is a drug.  However, how should this drug be administered?  How   specific   is   the   drug   chemically?     How   can   it   be   ascertained   to   be  behaviorally specific?   Drugs
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a. Routes   of   administration :     Intravenous   (i.v.),   intramuscular  (i.m.),   subcutaneous   (s.c.),   intraperitoneal   (i.p.), oral, sublingual, inhalated,  topical,   transdermal,   intrathecal   (i.t.),   intracranial   (i.c.),   and  intracerebroventicular  (i.c.v.).  Most common in animals are i.p., s.c. and i.v. for  peripheral routes that give drug to the whole body; i.c. and i.c.v for central routes  that limit exposure to the brain (i.c.v.) or a specific brain region (i.c.). b.
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Psyc404 Teacher's Notes - LECTURE 1 INTRO: Principles of...

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