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Unformatted text preview: LECTURE 4 INTRO: Animal Models of Mental Disorders and Behavioral Pharmacology Its only a model.- M. Python One of the major roles of behavioral pharmacology, of course, is the development of chemical therapeutics (e.g. drugs) for the treatment of psychiatric disorders. As an important initial step in this process (because we cannot just test random chemical compounds on undergraduate students) researchers create animal models of psychiatric disorders in order to initially evaluate pharmacological treatments. I. What is meant by a model ? A model may resemble the disorder in some fashion (for instance by producing a similar symptom such as anxiety or loss of appetite) which is similar to that which occurs in the disease, or it may simply allow the selection of effective treatments. There are several useful concepts regarding how well models accomplish their intended goals A. Validity : An animal model is useful if it resembles the condition it purports to model in terms of aetiology , biochemistry , symptomatology , and/or treatment . Meeting all of these conditions is not necessary for an effective model, but at least one should be met. In particular, in most psychiatric disorders the aetiology and biochemistry are often unknown or a matter of debate. There are several types of validity which may be established. 1. Face validity : Are the phenomena similar in terms of symptomatology or aetiology?...
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This note was uploaded on 10/18/2011 for the course PSYC 404 taught by Professor Staff during the Spring '08 term at Maryland.
- Spring '08