gen380F11StLect5

gen380F11StLect5 - GENETICS 380 LECTURE 5: Non-Mendelian...

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http://www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 5: Non-Mendelian Ratios Part I
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So far, we’ve used Mendel’s Laws to predict phenotype & genotype ratios in progeny from a cross 1 st Law Principle of Segregation 2 nd Law Principle of Independent Assortment Conditions that were true for Mendel’s Experiments: - all traits being considered are unlinked - genotype determines phenotype - every gene has 2 alleles
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YELLOW ROUND GREEN WRINKLED X P o AABB aabb ALL YELLOW ROUND F 1 AaBb YELLOW & ROUND GREEN & ROUND YELLOW & WRINKLED GREEN & WRINKLED F 2 9 3 3 1 GREEN X YELLOW YY yy ALL GREEN Yy 3 green : 1 yellow YY Yy Yy yy “Mendelian Ratios”
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- causes involving a single locus: - different types of dominance - multiple alleles - lethal alleles - causes involving multiple loci and/or environment: - incomplete penetrance - variable expressivity - environmental modification - epistasis - causes involving sex-determination: - sex-linkage - sex-influenced traits - sex-limited traits Why do we see inheritance patterns different from Mendelian Ratios?
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Dominance Relationships COMPLETE – phenotype of heterozygote looks like phenotype of a homozygote YELLOW ROUND GREEN WRINKLED X AABB aabb ALL YELLOW ROUND AaBb
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Dominance Relationships INCOMPLETE/PARTIAL – phenotype of heterozygote is intermediate between phenotypes of different homozygotes EXAMPLE: pink is intermediate phenotype x
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and Codominance 1 gene - codes for a sugar transferase enzyme - adds sugar molecule onto H antigen - on surface of all red blood cells - 3
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gen380F11StLect5 - GENETICS 380 LECTURE 5: Non-Mendelian...

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