gen380F11StLect6

gen380F11StLect6 - GENETICS 380 LECTURE 6: Non-Mendelian...

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http://www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 6: Non-Mendelian Ratios Part II
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- causes involving a single locus: - different types of dominance - multiple alleles - lethal alleles - causes involving multiple loci and/or environment: - incomplete penetrance - variable expressivity - environmental modification - epistasis - causes involving sex-determination: - sex-linkage - sex-influenced traits - sex-limited traits Why do we see inheritance patterns different from Mendelian Ratios?
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Suppression is an example of epistasis Suppressor Gene – gene that suppresses (masks) the action of another gene eye color in Drosophila wild-type (wt) = most common phenotype mutant = different from wt; rare Drosophila Nomenclature mutant allele 1 st letters of mutant phenotype dominant = upper case recessive = lower case wt allele “+”
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eye color in Drosophila p = purple; p+ = wt purple is recessive to wt (red) color Suppression is an example of epistasis s = suppressor; s+ = wt (non-suppressing) 2. - two genes involved: 1. recessive s allele masks effects of genotype at p locus
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PURPLE How do we recognize suppression? RED x ALL RED
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Complementation is an example of epistasis - wt phenotype arises by combining 2 different genotypes
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gen380F11StLect6 - GENETICS 380 LECTURE 6: Non-Mendelian...

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