gen380F11StLect7

Gen380F11StLect7 - http/www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 7 Pedigree Analysis How does X-linkage affect human heredity

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Unformatted text preview: http://www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 7: Pedigree Analysis How does X-linkage affect human heredity? - can’t test a hypothesis in humans by setting up crosses Studying heredity in humans is challenging: - difficult to see Mendelian ratios in family with few progeny - we must recognize patterns associated with modes of inheritance - pedigrees 1 2 1 2 3 4 I. II. 1 2 1 2 3 4 III. 1 2 3 4 5 IV. 1 2 3 p I. II. 1 2 1 2 3 4 III. 1 2 3 4 5 IV. 1 2 3 p PEDIGREE #1 PEDIGREE #2 PEDIGREE #3 PEDIGREE #4 PEDIGREE #5 X-linked Recessive Traits - if dad is affected: - if mom is affected: - examples: color blindness Duchenne’s muscular dystrophy - won’t pass trait to sons - all daughters will be carriers - all sons will be affected X-linked Dominant Traits - if dad is affected: - if mom is affected: - examples: hypophosphatemia (vitamin D resistant rickets) - won’t pass trait to sons - all daughters will be affected - 50% chance all children will be affected - all affected individuals have affected parent Autosomal Dominant Traits...
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This note was uploaded on 10/18/2011 for the course GEN 380 taught by Professor Glodowski during the Spring '11 term at Rutgers.

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Gen380F11StLect7 - http/www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 7 Pedigree Analysis How does X-linkage affect human heredity

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