gen380F11StLect8

gen380F11StLect8 -...

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Unformatted text preview: http://www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 8: Gene Linkage in Eukaryotes Chromosomes act INDEPENDENTLY during metaphase I and metaphase II Mendels 2 nd Law In Action Let A = seed color B = seed shape Fig 2.17 p.31 a A b B many combinations of alleles are possible in gametes If A & B loci are on different chromosomes ab AB aB Ab aB Ab ab AB In humans, ~20,000 genes are distributed among 23 pairs of homologous chromosomes LINKAGE is observed as a deviation from independent assortment toward P (parental) gametes First, lets review Independent Assortment AABB x aabb P 0 gametes AB ab F 1 AaBb gametes AB Ab aB ab LINKAGE is observed as a deviation from independent assortment toward P (parental) gametes STATISTICAL Linkage PHYSICAL Linkage A B C based on experimental data how we observe physical linkage physical proximity of genes on a chromosome The most extreme linkage is Complete Linkage - genes are so close that they never assort independently In Drosophila, all genes on chromosome IV are completely linked Drosophila Chromosomes - lets look at 2 of them: shaven (s) bent (b) Let s + = wt s = shaven Let b + = wt b = bent ssbb x s + s + b + b + P 0 s + sb + b F 1 s s b b s + s + b + b + s + b + s b ssbb x s + s + b + b + P 0 Linkage Nomenclature s s b b s + s + b + b + s + sb + b F 1 s + b + s b What weve done before:...
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This note was uploaded on 10/18/2011 for the course GEN 380 taught by Professor Glodowski during the Spring '11 term at Rutgers.

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gen380F11StLect8 -...

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