gen380F11StLect11

gen380F11StLect11 - GENETICS 380 LECTURE 11: Structure of...

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http://www.cellimagelibrary.org/images/10086 GENETICS 380 LECTURE 11: Structure of DNA
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GENETIC MATERIAL - contains information - is stable, but must also have the ability to change - carried on chromosomes Is genetic material made of protein or DNA?
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Hypothesis: Genes are made of protein. - protein has good potential for variability - rejected due to results from 2 different experiments: 1. Griffith (1928); Avery et al (1944) 2. Hershey & Chase (1952)
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Griffith’s Experiments studied Diplococcus pneumoniae 1. Smooth (S) 2. Rough (R) - colonies are smooth & shiny - wild-type - virulent (infectious) - cells are enclosed in polysaccharide capsule - no polysaccharide capsule - nonvirulent (easy to engulf and destroy) - mutant
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Are living cells necessary for virulence? TRANSFORMATION = conversion of rough smooth Griffith’s Experiments S (virulent) inject DEAD R (nonvirulent) ALIVE Boiled S ALIVE Boiled S + living R DEAD
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What is the TRANSFORMING PRINCIPLE ? What is in cell debris that can convert R bacteria into S?
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This note was uploaded on 10/18/2011 for the course GEN 380 taught by Professor Glodowski during the Spring '11 term at Rutgers.

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gen380F11StLect11 - GENETICS 380 LECTURE 11: Structure of...

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